I agree that a .41rf is probably better than a 1" .22rf, but the "best" pocket pistol ever, that I have a hard time with. If you like the two shot derringer, Remington copies have been made it .38spl, .357, .44 mag (I don't want to be around when that one goes off), and probably bigger calibers.

But if you define pocket pistol as a pistol you can carry in your pocket, I carry my Kahr MK40 in a DeSantis pocket holster all the time, and I will take it over any two shot ever made...