.357 is too heavy for most ladies. Unless she's a trained shot. Recoil from the first round will rip the gun right out of her hands (from not holding it properly). Get her a .38 Ladysmith. Load it with MagSafe's or Glazer Safety Slugs. Much lighter recoil and one round anywhere in the center of mass is uniformly fatal.
_________________________
I don't do dumb & helpless.