For years, Smith & Wesson has put out a line called the Mountain Gun. It comes in a different caliber every year, rotating among .357mag, .41mag, .44mag and .45Colt. It is specifically designed for backpacking as they have lightened the weight by making it a half lug underbarrel, and decreasing the outside diameter of the barrel. It is not designed for 100,000 rounds of hot magnum loads. It is a great gun to shoot. My g/f has the .357mag model. Personally, I am waiting for the next round of .44mag to come out. I don't know what this year's model will be.
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It's not that life is so short, it's that you're dead for so long.