Paracetamol / acetaminophen / paracetamol is a safe antipyretic and antiemetic.<br>The dose which will cause toxic liver damage in an adult is >10000 mg (>20 500mg tablets).<br>This is was beyond what the recommended daily dosages are.<br>Paracetamol overdose can cause fulminant liver failure in an overdose but there is an antidote - N-acetylcystine. This of course has to be given ASAP.<br><br>So just stick to the recommended dosing and you won't go far wrong.<br><br>However, even prolonged use of aspirin and ibuprofen at the recommended dosages can lead to gastritis / gastric erosions and even gastric perforation. This is because of the continued effect of inhibiting one of the enzymes which plays a part in the gastroprotective mucus secretion in the GIT. <br><br>SO long term uses of NSAIDS also has its inherent risks.. :-)<br><br>