Yep, I've had to run (to the bunkers mostly) with my SRK on my ankle a couple times, no problems. I tuck the tip of the scabbard into the top of my work boot about an inch and a half down, I have a nylon strap threaded through the top of the scabbard with a plastic clasp on the ends that allows me to wrap it around my leg just below the calf muscle. It ain't the most comfortable, but after a while you don't notice it much. I really like the way the knife compression locks into that scabbard. I put another SRK into my BOB, just in case I have to bug late at night after being rudely awakened and can't dress down like I usually do.
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The ultimate result of shielding men from the effects of folly is to fill the world with fools.
-- Herbert Spencer, English Philosopher (1820-1903)