Alan: My cousin the (IMO very learned) Oral Surgeon, some time back, told me of a blurb from a medical journal she had read, discussing the effectiveness of the Tylenol,Advil/ caffeine mix, in the dosages I described. It was in the context of post oral surgery pain relief . She said the article said that mixture worked as well, in early ( anecdotal) reports, as the mild narcotics or Motrin, often prescribed for such post surgical pain She also mentioned that she had tried it herself, as had some family members and found it worked as effectively as stated. But if you took my use of the word “ reports” to mean formal studies, then no, I haven’t read any to the that effect.. However, adding to the anecdotal evidence, the combo has worked for both my wife and me, after dental l surgery.