My MB is mostly used on streets. Fat slicks may not be as fast as skinny road tires, but they make great tires for use in a city with potholes and cobblestone streets with the occasional gravel bike path. I have never (knock on wood) had a flat.
Coming from the other direction, I gave up skinny tires for fat (38mm) road tires for both commuting and touring. They were much better on surfaces other than pavement.
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