Every time I'm at my local multiplex I have a Surefire E1B and a handgun, usually my HK P30S or HK VP9, and both wear tritium night sights. With either of those guns I'm probably going have a very high percentage chance of a head shot within 50 feet and I regularly practice out to 25 yards with them.
I've done a course with moving 3D targets (bad guys) and moving "no shoot" non-targets, where you had to be constantly on the move (sometimes involuntarily -- i.e., panicking crowd shoving you). Crazy guys do not move in a smooth, predictable way, and that was simulated (i.e., not shooting ducks scrolling smoothly from left to right at a fair). Even at half the distance of what you're talking about, it was really, really hard. I'd recommend a course like this.
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