I have found that TSA will not search my bag if I ziptie each compartment shut. Ziptying the the zippers togther, that is.

I have found their notice of search in my bag (not sealed) and I have seen where a bag was searched (my E&E Kit enclosed) with no notice being left. I haven't "lost" anything yet.

Should be noted, I don't fly commercially unless there is no other choice.
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QMC, USCG (Ret)
The best luck is what you make yourself!