Thats why I have two different kits. One is a Camelbak backpack which fits the normal BOB stereotype. I then have a suitcase/travel kit for those kinds of situations.
I built that kit based around us doing some traveling ourselves and reading different travel sites where people who travel for a living. I keep a good sized toiletry kit always stocked and rotated which has a small first aid kit. Then when I buy new things like socks or underwear I buy two packs and put one in my dresser and one in my travel kit. So as I buy new stuff it goes in the kit and what was in the kit goes into use.
Of course now when we travel I take both kits