Yes, being willing to anticipate problems can go a long way toward mitigating them. As has often been said here, it's not usually just a single problem that gets you into real trouble, but multiple problems at the same time, and the world-famous 'snowball effect'.

I hope you have a good trip. What kind of pup is your friend getting? Be sure to take towels, as many pups get carsick. When I got my last one, she thought the best place to ride was wedged between the back of my neck and the truck's rear window. Sixteen pounds of fluff, scrambling and barfing...

Sue