The OTC medications in my FAK are frozen and unfrozen repeatedly over several months every year where I live. Advil, Benadryl, Pepto-Bismol and decongestants all continue to work, without any noticable loss of efficacy. Neosporin-treated boo-boos don't get infected.

I wear disposable contact lenses, and I'd really like to stick a spare pair and some solution in my BOB, but I doubt they'd survive the frequent freeze/thaw cycle.