Originally Posted By: CityBoyGoneCountry
But the enormous size of the universe means that we'll never be able to explore all of it, and if there is life elsewhere, they're probably having the same problem.
Yes, that's the crucial factor. Especially if you accept the speed of light restriction (and if you don't, you aren't really doing science any more).

In addition, there's a big difference between life and intelligent life. Life appeared on this planet as soon as conditions made it possible, but life capable of, eg, building a radio telescope for communication only appear very recently, and we have no guarantee it will not go extinct within a thousand years of achieving that. So the chances of getting two species, within 200 light years of each other, both capable of communicating/travelling across that gap, and both appearing at the same time, may be vanishingly small.
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