To a certain extent, I like combining some PSK/FAK items. In my med/large PSK (an Otterbox 1000) I had enough room for 3 triple antibiotic packets, 2 alcohal wipes, 2 2x2 gauze pads, 4 bandaids, and 10 steri strips. The idea being that if I were to suffer a large gash from a fall or something I could patch myself up if all I had my my PSK. I could also use the 26" of duct tape in the kit, and my EDC cotton bandanna for additional wound dressing. But again, those supplies are in there just in case all I had was my PSK. Additionally, I carry the AMK Ultralight .9 in my pack, so I can deal with just about any medical emergency I encounter.
Sometimes, when I am going a little lighter, I do like to break up my PSK and FAK. I have found the Otterbox a tad too uncomfortable (hard, and 12.3 oz) to sit in my pocket all day, though I have managed that before. So like many others, I break my supplies up and carry the Ritter PSP in one pocket, and my personally assembled FAK that I call my Ultralight ".4" - it is about halfway between the .3 and .5. This way I can carry more medical stuff, though slightly less "survival" stuff, than what is in my Otterbox in a more comfortable setup. I love my Otterbox and AMK .9 but sometimes they are awkward to carry on person and thus I usually toss them in my pack, but the nature of my environment (urban at the moment) makes a pack feel like overkill. Can't wait to go hiking...
Matt