This might be cheating a little, but the Leatherman Wave I have is probably my first choice. The blades do lock, but more importantly, it is a true multi tasker, which puts it at the top of my list, and having seen a guy field dress an elk with his, I know it will do all that I would need of a folder.

However, if it were a dedicated folder, and price were no object, then the illusive Busse folder would be my knife of choice.

Since that knife is not available as yet, the Ritter MK4 is probably the goto knife for the money.

The KA-BAR desert Mule that I currently EDC is probably the best value for money for a dedicated folder with the qualities I am looking for.
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The ultimate result of shielding men from the effects of folly is to fill the world with fools.
-- Herbert Spencer, English Philosopher (1820-1903)