"Rule 2 - Never point a gun at anything that you are not willing to destroy"

A rule that has probably saved more computer monitors over the years during "system crashes"

As to the original question, legally blind persons get driver's licenses every day. Most concealed carry laws require a proficiency test which not only includes the "legal" and "liability" questions but also include a shooting test. Now I have seen many of these tests which only require the shooter to hit a target at a short distance (usually around 21 feet) with 70 percent accuracy (7 times out of 10).

The tough part (at least here in Michigan) would be to convice the "gun board" (usually made up of the Sheriff, State Police, Prosecutor, and a County Council person) that you are the correct person to be given the permit.