This morning I watched him pull the knife out as a lefty (hold case with right hand and pull knife out with left hand - the exact opposite of what I do), then switch hands, open the blade with his right hand, and then switch hands again.
Ahh.. The curse of the left-handed people..

I'm also left-handed(and use a 'old' Leatherman Wave and a Squirt BTW) and from my experience, you get used to switching from hand to hand every time.
I do wish LM would come out with a left-handed version of the new Wave to address that issue.
So would a lot of other things...

If you'd ask me: Leatherman New Wave hands-down.
Take care