I am not an expert, but I have a blind spot in the center of my right eye due to an injury in high school. Since then I have shot rifles and shotguns left handed. My favorite hunting rifle is a left handed bolt action, and my shotgun is a pump. Pistols I still shoot right handed by simply holding the piece an inch or so to the left while sighting with my left eye. At pistol ranges I can't tell the difference. My advice is to at least give left handed shooting a try, particulary with long guns.