I did a bit of an experiment a while ago to see how aspirin and a couple other "heart healthy" OTC items would affect me. I was taking the standard enteric coated aspirin dose of 325 mg/day, along with a vitamin E supplement, an Omega 3/Omega 6 supplement, and colloidal mineral supplements. After 7 days of this therapy, I started having nose bleeds every time I blew my nose, I experienced rectal bleeding (a bit alarming that) and I noticed that abrasions and cuts would ooze a bit longer. My conclusion is that if you are taking these items, a therapeutic cardiovascular dose is considerably lower than the maximum dose recommended.