My wifes ex husband has a major case of it. In his early 40's he suddenly divorced her, married a younger gal (who now looks about ten year older and 50 pounds heavier than my wife does), joined a motorcycle "club" (they wear nasty Levis, do-rags on their heads, tatoos all over the place, are on a first name basis with a lot of Hell's Angles), spends even more time in the gym pumping iron (he already had biceps the size of most thighs), and has a major combover going. He has been stuck there for at least 15 years it appears, with no end in sight.
I, on the other hand, lost my hair, no big thing, finally got into got the kids out of school so I could get out of a marriage that had died 20 years before, and am happy as a clam all the time.
Guess it depends on the individual...
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OBG