I have used Delorme Topo USA 5.0 in excess with great success and just bought 6.0 and find it an improvement over 5.0. I have never used Delorme’s GPS receiver but I have used the software with a Garmin and Pharos Receiver and the program worked perfectly.
I will warn you that the program does take some time to learn properly and get full function out of it. Once mastered it can be an extraordinarily useful tool. Its biggest benefit to me is printing custom topo maps and being able to add data to those maps that I collected with my GPS.
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"Trust in God --and press-check. You cannot ignore danger and call it faith." -Duke