It isn't the topical treatment of wounds with stuff like mycitracin or neosporin that causes resistance but rather the systemic use of antibiotics on a frequent basis. For example, we go to the doctor for colds and sore throats. It is a known fact that unless you still have your tonsils most likely your sore throat is of viral origin. That notwithstanding, you will receive a 10-day course of whatever the latest broad spectrum antibiotic the last drug rep was by with (I used to be one years ago). IF the sort throat was bacterial and not viral the most likely pathogen would be strep. Then the drug of choice is STILL penicillin. Not only would it work but it would cost pennies. You wouldn't get that. You would probably get Levaquin for a small fortune. That's why the cost of medical care has skyrocketed and bacterial resistance to antibiotics has become such a real problem. Nothing more complicated than that.