As a hotel worker, I gotta chime in on this one.

#1) Do NOT leave any valuables in the room while you are not in it. Use the safe provided or go to the front desk and ask to use a safety deposit box.

#2) Locks. When in room, use the deadbolt and the "chain". Even with electronic locks, if you deadbolt the door, no one can get in, except with a master key that only the GM and fire dept have access to.

#3) If you are on a higher floor, windows should not be a problem (unless Spiderman goes bad). But if on a lower floor, make sure the windows have those "lock bars" on them so the window can only be opened part way (except if you remove the "bar")

Any other questions, fire them at me.