Anza-Borrego desert state park is a great place. I have spend many weeks there. Be sure to go to the visitors center and see what they may have going on. They have some marvelous collections. You will enjoy the place much more if you understand the environment and history.

Never had snake problems. If you touch one of those cactus with the small fur like barbs you might try white glue (lke Elmers Glue). Put a small amount of the white glue over the area and let it dry. Then peel it off. The barbs will come with it. Otherwise they are very hard to remove.

Your most serious danger will probably be dehydration. Water in your canteen does no good. Drink as much as you can. Don't ration it.

Take some sort of hiking staff. A turned ankle in the back country becomes a real problem for you and the people you are with.

Mostly, enjoy. It is a pretty safe area if you think before you act. It is also one of the best places to enjoy nature. After you get your fill of AB, consider Joshua Tree NP. Another wonderful place.

enjoy enjoy.