I used to EDC a Boeker Speedlock. I changed this because of additional requirements. The onehanded opening is an advantage. The Speedlock can also be folded with one hand. It locks reliably and I never had any problems with accidental deployment despite the lack of a safety. One weakness was the spring. Most models have flat spring that may break. I selected the Speedlock because of the helical spring and the ease of taking it appart. The spring isn´t particularly vulnerable and it can be replaced with few tools and average skill. It´s also easy to clean.
I never found a OTF that would lock the blade reliably. Many allowed pushing back the blade by pressing the tip with a fingertip without spilling blood. Another weak point is dirt. If you can´t take the knife apart it may hard to keep clean. I saw gravity operated knives that were so dirty that they almost failed to operate. They could only be brought back to operation because they could be taken apart without too much trouble. I never own a OTF. I would have bought one as a collectors item but they´re outlawed now and it´s not worth the risk.