As others have stated, a .22 is capable of being used in self-defense, but probably not the best choice. However, the old saying is that the 22 in your pocket is better than the 45 that you left at home. So if because of size/weight, you decide that the 22 is the best that you will carry, then carry it happily. The .22 will also have some benefits as far as also being able to take small game without destroying all of the meat, so it is a true multi-purpose device.

Chris: The reason that trauma surgeons don' tlike .22 is because that is what they see. .22 victims go to the ER. .45 victims go to the coroner <img src="/images/graemlins/grin.gif" alt="" />