Trauma surgeons consider the .22 the worst wound to work with. Aside from a very small tearing wound channel the external lubricant introduces all manner of nasties.
The inherent accuracy and ease of shooting also make it a prime tool. A handgun's role is to stop the assailant from stopping you: not kill ,maim or introduce nasty wound channels for doctors. There are documented shootings where the .22 worked: and there are others where full magazines or chambers of .45acp and .44magnums DID NOT. So there literaly is no 'magic bullet' If this is what you have, practice and be as good as you can be.