I'm not sure if they are still in business, but I've always liked my Eagle Creek backpack. I used it for college...three times...and I'm still using it today. It's always kept in the insides dry, even in heavy rain, and the zippers are, as the company says, "practically bomb proof". If you're looking for something along those lines, that would be my two cents.

I've been researching a Sleeka Force 35. As I understand, it is waterproof with a built in/ stowable camo rain cover for extra protection. No frame I don't think, but I believe some miltary folks use it.