Always have more than one backup via more than one method. IMHO ghost is not a backup tool. I know they have added some backup software like features in recent versions because it gets used that way, but its primary use was to quickly image multiple workstations for IT shops unwilling to learn technologies such as unattended setup. You should use more than one method, for example copy data to an external hard disk each night but burn data to CD's each month.
I have my most important data on a usb flash drive which is part of my edc so even with the complete loss of my systems and backups I still have my most important data (address book and calendar which journals my live for the last 10 or so years), then incremental backups on an external hard disk and copies of important stuff on cd's stored in various locations.