Re: meat destruction -- that's why I do head shots. I haven't hunted for horns in over 30 years.
This whole issue of survival weapons is kind of misplaced, I think.
The selection of a proper weapon begins with (1) training, goes to (2) environment, and ends with (3) intended target
If you are asking this question, you aren't trained to shoot people, so scratch that except REAL close and last ditch. Where do you want to kill something? what range? Finally, what for you want to kill?
Honestly, you can find extremes of position on ballistic adequacy all over the place. A 22 Hornet on deer is, sorry, an extrenme position. By some minds, so is a .223, but because of bullet selection, not because of other factors.
In my environment, if you want to feed yourself with a gun, it is going to be with birds, or sqirrel, or rabbit. Deer you can do, but don't count on it ever day in every way.