NO! Some weapons are set up to handle the .410 interchangeably with .45 colt and .45-70 rounds ( ie the Thompson centerfire system.) One potential problem is piercing the primer with the heavier pin throw with associated gas blowback in a dedicated .45-70 and jamming the action/barrel with the spent hull components. The reverse idea is even more dangerous; loading a .41 magnum into a .410. goodbye shotgun, fingers and misc. facial accouterments ( eyes, nose, teeth.) There are various combination weapons, interchangeable barrel systems and inserts ( recently mentioned.) Small game calibers will harvest just that; small game that can be secured with snares and improvised weapons. If a weapon is desired, a suitable centerfire can potentially take larger game for the same weight expense. I started out with a highly modified M6 scout, moved on to a large bore bolt action and graduated to a coil of 26 guage wire.