You'd be doing yourself out of half the fun.   
But, OK, you want to make a serious run at it, I went back and looked at your original post and some of the responses.  
I have, after reading your posts ADDED aspirin to mine.  I've been carrying ibu only.  But, I have eliminated most of the packaging of the meds.  Trim down bubble packs, consolidate loose tablets -- harm in it.  The things like the sting pads, they are bulky -- do you need three?  
You know your usage/travel patterns: is the fishing gear urgent?  Could you not elimiate a lot of it?
Is your problem primarily weight, or bulk?Your kit is so much like one of mine, I don't know what else to say.  Unless you just go the Ritter Kit route for pure minimalist utilitarianism.