The biggest difference in COX-2 inhibitors and NSAIDs such as motrin is not their pain control or ability to reduce swelling, but that the incidence of GI bleeding was less with the COX-2 inhibitors. For indiviuals that don't have a history of GI bleeding or ulcers, most should go with Motrin. Best to discuss this with YOUR doctor, who knows your medical history and can take into account all the above factors and come up with a plan.