That's exactly it - the one-handed blade opening trumps all else.
I didn't fully realize it until I "inherited" the Flair from a friend of mine - the Wave was my first Leatherman (before that was all SAKs).
For such a simple modification, putting the blades so they come out on the outside, the advantages are manyfold. One-handed blade opening, locking blades (although some of the new Leathermans have all locking blades on the inside as well), the handles are more comfortable because when you use the pliers you're pressing down on the rounded blade covers and not the metal edge, and as an undocumented feature, when the pliers are open you can use the space between the file and the serrated blade as an impromptu crimper (or nutcracker, I suppose).
Frankly, I'm shocked that anybody still makes multi-tools, other than the tiny ones, in the "old" way.
I also can't understand the fascination with putting a zillion screwdrivers on these tools. Anyone who has serious need for screwdrivers will buy the tool adapter. The blades included on the tool are next to useless because they are off-center and at least to my clumsy hands, the blade keeps sliding out of the slot because I'm driving off-center. It doesn't help that they're polished either. And the space used for the screwdrivers could go toward much more useful tools - I'd love to see a Leatherman with an awl. A corkscrew would be nice too, or a mini-fork or butter knife (these are the tools found on the Flair, and nowhere else, and if I think I'm going to use any of those, I carry the Flair). Another possibility would be a strikable flint for firestarting.