I personally wouldn't want one of these super powerful handguns, but if I were to get one, I think it would be a .460 S&W magnum, which is only a small step down from the current king of the hill, the .500 S&W magnum. Then when you get tired of blowing your hand off, you can switch to .454 Casull. Which will still blow your hand off, but a little less so than the .460's. And when you finally get older and less macho, load it up with .45colts or even .45 Schofields. I've never shot the .460 S&W before, but .454 Casull I have. It has recoil for sure, but I didn't consider it punishing. But if you're not a long time experienced handgun shooter, that .454 Casull will probably do most folks in. I can't imagine the .460 or .500 S&W... Unless you have a specific need for a cartridge of this power, and such need would be extremely rare, I can't fathom any reason someone would want one. .45colt, on the other hand, is my absolute favorite handgun cartridge. Plenty powerful, easy to shoot, easy to reload, and the SAA revolvers chambered for it are my favorites.