Although I will say that I tested the Delorme InReach in some canyons in Northern Arizona last year and had 100% communications with it, but they would not be considered slot canyons. This was only the satellite communications, not the PLB signal of course.
The InReach does not use COSPAS/SARSAT for emergency signaling -- it uses the Iridium satellites for all communications functions. Anywhere it works for text messaging it will work for emergency signaling, as long as it can obtain an accurate GPS fix and GEOS (the private RCC) is working.