Much of the problem in 2nd world countries is lack of strong infrastructure.
The US infrastructure ain't that great in many places either. And with the emphasis on just-in-time re-supply, pretty much any American tourist center that is cut-off from vehicular traffic is going to have serious problems in a matter of days, too.
Even the Fukushima region in uber modern Japan suffered widespread re-supply issues. For a number of reasons, trucks were unable/unwilling to drive into the region so food and fuel all ran out very quickly there. I'm still haunted by the video posted by the mayor of a small town in the region pleading for help after the quake and tsunami devastated their town.