The comments above are too funny. Seriously though, survival is a mindset and it really doesn't matter much where you are. You should be thinking two steps ahead rather than reacting to something unforeseen. In the case of a hotel, I'm usually ready to walk out the door and down to the lobby -- would never get caught outside the room nekkid. EDC items come to mind; when I'm living in a hotel, that keycard thingy becomes part of my EDC.

Totally OT: Surviving a bombing in a large crowd is easy -- don't be there.