I don't have any family for a thousand miles but have considered whether I could leave friends and neighbors. Can't really know unless it happens. The bugging-out logistics of the metro area I live in are so daunting that I've pretty much dismissed the possibility in any kind of urgent situation. The roads would be absolutely gridlocked, which they already are much of any normal weekday.
Perhaps a hurricane with days of notice....
I'd be working my 80-year old parents into my plans -- for the likelier shelter-in scenarios as well as the bugging out scenarios. With 80-year olds, one of the considerations likely will be medications and ensuring that they have enough of the meds they need to survive.
I've become less oriented toward bugging out from home and am focusing more on having some preps in my vehicle at all times just in case I'm already away from home when something happens. I'd be okay living out of my car for a weekend - including food and water. Then I'd have to hoof it with the backpack I keep in there.