Yes, it won't be as quick as with a smaller branch but doable. Remember these saws aren't like bow saw that has attachment on both ends, so you can pull it almost all the way out with only an inch or two still inside the tree, so this effectively made the saw longer.
I've cut 4" wood with my 7" saw, getting slow but can be done.
GradyT34 mentioned about the possibility of a 10" limb or tree coming through the roof of his home during a hurricane. If this were me and I was planning to cut up any potential fallen trees of this size with a handsaw such as the Genki-Temagari 500 or the Katanaboy, considering their price at close to $200.00 per, I would instead be looking at a good used chainsaw which depending on the area and local supply / demand, can be had for not much more then either of these saws.
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Earth and sky, woods and fields, lakes and rivers, the mountain and the sea, are excellent schoolmasters, and teach some of us more than we can ever learn from books.
John Lubbock