.net is frustrating. It was too slow to use on my netbook because of it and I can run things like google earth fine. Other computers fall into the normal .net versioning issues and I see so many problem with other developers apps because of .net.
I have an older XP computer. It did not run anything including basecamp very well until I got more memory.
The reality of MS OS is that they are memory hogs. Any application running any version of windows has always had this issue.
I have never had any issues running basecamp other than when I had a lot less memory. Given that the issues went away when I got more memory, I doubt it was a .NET issue.
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Warning - I am not an expert on anything having to do with this forum, but that won't stop me from saying what I think.

Bob