I have not taken children on long air flights to distant lands but I have observed parents with small children on my trips each year to India. The 21 hours of flying time involving one connecting flight with the same families was an obvious ordeal for them. Children just get impatient with the sitting for so long. The most successful parents seem to get the kids up about once an hour and walk up and down the aisles. They have coloring books and small, quiet toys for them to play with in their seats. Also, the airlines seem to really plan for this by putting these folks on bulkhead rows so they have a little more room. Of course travelling first class with kids would be the best but such seats on my flights are about $12,000.00, which is out of reach of most young families. Once in a country such as India, you have to remember not to ever drink the water and even when showering to keep eyes and mouth shut, especially for children, whose immune systems are not quite as robust as adults. When ice is offered it is best to refuse it because it is usually made with tap water, so is not safe. Some hotels actually advertise that they make their ice with bottled water. In the large cities you can find McDonalds and even Taco Bell and Kentucky Fried Chicken and in Bangalore, the only place in India I could find an actual beef pattie in a hamburger was at a Hard Rock Cafe. I would imagine that anywhere in the Western Hemisphere you should be able to find the kind of junk food that kids seem to require. If you try the local foods, kids usually do not like them because they are not familiar with them. When I travel I carry two courses of Cipro for a number of reasons and one of Flagicillin for terrible dysentary or parasites. I have not ever contracted the guinea worm parasites, thank goodness, but one does not know till they bore through the side or bottom of your foot a year after entering your digestive system and have to be pulled out surgically and are about three feet long! You will need some kind of tube of anti-biotic creme for small scrapes and cuts, etc. And I take an anti-malarial profilaxis, arythromycin, which I start a few days before leaving and take the whole time I am in India and then for a month after returning home. Remember to spray Deep Woods Off on the children especially when going out but remember, often the greatest danger is at night while they sleep so prevention is the key. These would be considerations for small children anywhere mosquitoes are found and sanitation is questionable and unreliable potable water. Remember, these very interesting places are great for adults who follow take the cautionary medical advice seriously.