I used to commute 45 miles each way when I was living in NE Maryland and working in downtown Baltimore. The morning drive wasn't too bad (I left the house at 5AM), but in the evenings the slightest traffic hitch couple mean a couple hours to get home. The worst was a 3.5 hour slog when a major accident closed I-95 and I was 3.5 miles from an exit in either direction.

Thankfully I drive back roads to a much closer work location now, although recent changes in the local employment picture and a lack of road improvements to accommodate the changes could mean a longer travel time before too long.