The combo of a major quake and Santa Ana winds would be a very bad combination for Los Angeles. Not only because of the risk from natural phenomena and firestorms, but also because as you know a few nut-jobs seem to show up every year and start man-made fires at that time. Fortunately, statistics are probably on our side. The chances seem unlikely - although far from being impossible.

I have the actual shakemaps that have been calculated by USGS scientists for the rupture on the Southern San Andreas. You can find them online. I enlarged them and printed them digitally. I studied them carefully for quite a while, and decided that the results are NOT encouraging. USGS simulated a 7.8 magnitude quake for the San Andreas, so real results would be worse if the Big One is stronger.

Pete2