This is essentially what I meant upthread.

Regret - a sense of loss, disappointment, dissatisfaction, etc.

Regret - a feeling of sorrow or remorse for a fault, act, loss, disappointment, etc.

Based on those definitions I'll go with most people will have regrets - hopefully for smaller things. If you live a life without regrets you are amazingly lucky/blessed in your experiences and choices or you may fall outside the human norms for emotional responses.

Life is full of choices and these can lead to regrets - choosing wisely and intentionally with your long term goals in mind can go a long way to reducing and eliminating regrets.

To me the goal of life is to have few major regrets since regrets have no intrinsic value. I have also learned lots of lessons from experience without collecting regrets.

- Eric

A little science to add to the mix:

http://scienceblogs.com/deanscorner/2011/06/what_americans_regret_the_most.php