After driving the route home late this afternoon, I realized no matter what gear and experience a person has, this country is simply too rugged and unforgiving to attempt a walk home.
I don't buy into giving up.
I would agree that walking home is pretty much your last option and makes trailer with jet-boat look like a sensible item of preparation for a road trip :-)
But consider that someone, several someones likely, in the past explored their way along that route. They didn't have the benefit of road/railways or man-made clearings down near the river. You might have to bushwhack when the road/RR is on the other side of the water but the initial explorers had to thrash the entire way. If the river is crossed frequently by bridges you wouldn't have to walk the whole way without a road even if all the bridges are down.
(that might be an interesting research question- just how DID that routed get explored?)
To me the biggest single issue would be food supply for the distance. Surely the explorers packed supplies on a mule or horse train. And they supplemented with hunting/fishing. While we might have modern clothing, footwear and stoves, we generally don't have 200 miles worth of even lightweight food stashed in our backpacks. Nor do we usually have pack animals to carry it for us.
Late additional thought- it might be a worthy experiment to pick a section and just try it and see what you'd learn. Often there are game trails that only appear after you've spent some time adjusting your vision to those details.