I made a Bug-Out kit based on the Ready.Gov recommendations, a long with some additional items of my own choosing.
My main BOB is a duffle bag which contains the following:
-Copies of my important papers and cash in various denominations and types
-(3) 3 Liter jugs of water
-Food for at least 3 days
-Mess kit and pocketrocket stove with fuel canister and lighters
-Two changes of clothes (in dry bags) with a heavy fleece jacket
-Stuff for water purification
-A winter hat, light work gloves, heavy gloves
-Toiletry items (soap, comb, toothbrush, toothpaste, deodorant, mirror, ect)
-A light weight synthetic sleeping bag
-A metal Nalgene bottle and belt case
-Toilet paper
-garbage bags
-a big tarp
-some basic hand tools (pliers, vice grips, adjustable wrench, screwdrivers, a Leatherman multi-tool)
-a sewing kit and first aid kit
-duct tape
-550 cord
-disposable ponchos
-a white painters suit with dust mask and goggles
-an AM/Fm/Shortwave radio
-a GMRS/FRS/WX radio
-Garmin GPS
-Two LED flashlights (Gerber Omnivore and Surefire LED G2)
-Spare batteries
-an Estwing camp axe
-an 18" Stanley Fatmax pry bar
-A Henry youth size .22 rifle with 200 rounds of CCI ammunition
I keep it by my back door with my boots and jacket. I basically set it up so, if I'm asleep in bed, I can get dressed, grab my EDC on my dresser, then grab my boots and BOB on the way out the back door, finally getting to my truck...all in essentially one quick linear motion.
I'm single now, but if I had other members of the family I would also make up a backpack BOB for each of them. The biggest things for them would be to make sure they have their own food, water, clothing, bedding, flashlight, cash, and a two-way radio for basic communication...then whatever else they might need specifically (medication, toys, ect).
I was right outside of New York during 9/11 and it was amazing how fast it could go from calm to complete chaos. I figured that, if I was ever in a situation like that again, I would want to be able to grab my stuff and get away as quickly as possible (hopefully, before most other people start clogging the roadways). The longer one waits the exponentially worse things can get.