Random thoughts.
Over time, the personal hygiene towelettes have ALWAYS dried out on me. They don't seem like they should, but they have. At this point I don't bother anymore.
Food tends to get crushed and otherwise get nasty over time. I've taken to protecting mine by putting in a hard case and stick with crunchy foods instead of soft foods.
As suggested, swap out the iodine based water tablets for Micropur. The iodine tablets can get pretty nasty if the seal on the bottle is not perfect. The Micropur individual packaged tablets are the cat's meow.
You probably don't need the mosquito net. :-)
You probably are better off with more, larger zip ties than different sizes. Probably don't need the twist ties.
Add water to your leave-at-office kit. Lots of water.
I'd beef up my travel FAK and optimize my leave-at-office FAK to be trama only, but that's just me.
I'd also try to keep in mind what you have in your FAK for convenience, and what you have for actual first aid. This helped me a lot, and now I actually keep them separate. This means I don't raid the FAK when I have a headache. This also helps the actual FAK to be smaller, and more focused on more serious problems.
Keep your cell on your body. You may not have the chance or ability to go back for it.
I'd also keep the chargers. I have plug in, 12v and AA battery powered chargers in my kit. But, I'd suggest trying to make the system as generic and interchangeable as possible. All mine are USB based, and I carry a very short micro and mini USB cable.
I'd love to add a decent portable solar panel to this mix, but haven't managed to yet as the decent ones appear a bit bulky and expensive.
Review your batteries against your actual (projected) needs. It is easy to over-do it on batteries, and it is easy to get the wrong mix (use up all the AAs but have too many AAAs or some such). Standardize on a battery type if possible. Check to see if your specific devices will accept the lithium cells (for example, my GPS will not operate on lithium batteries).
Truecrypt is
excellent encryption for USB drives, multi-platform and free!
With regard to GPS in phones or other similar devices, make sure you find an application that has off-line map capability and make sure you download the maps you may need ahead of time. You don't want accessing your map to be dependent on Internet access!
On the Apple devices, I like MotionX GPS application. I have a dumb phone, but I have the MotionX GPS application on my iPod Touch and iPad. Both are jailbroken to allow me to use a bluetooth GPS module (BTstack GPS).
My assumption is there is a similar package for Android based devices.
The other thing to consider here is that having a device that you can actually read information on is going to be handier than the USB stick. On my devices I use an encrypted "password" application called eWallet which can sync to my PC to carry any private data I need and I also have a bunch of non-sensitive data on there (reference materials, etc.).
Note that with the iPod Touch and the upcoming small Android based tablets you don't need an expensive data plan to have these types of capabilities.
WRT radio scanners, note that a lot of stuff has gone digital trunked around here, so it is useful to have a scanner with that capability. That said, the digital trunking capable scanners are expensive and bulky, non-intuitive and tend to need some pre-programming to be useful. I'd love it if someone can point me to a device that proves me wrong.
WRT boots -- if your boots are too heavy to wear comfortably all the time, I suggest you look at a different pair. I wear my Vasque Sundowners year round, all the time. They are basically a light weight hiking boot, but have full ankle support.
Basically, Murphy says that if you don't wear them all the time, that you won't be wearing them when something happens. And sensible footwear is high on the list for a 20 mile walk through rubble.
As noted before, you want the basics on your person at all times. I'd move your knife to your body, and perhaps a small flashlight. When it comes down to it, what you have on you is the only thing you can count on having at all times. I've added a firesteel to my on-body kit for this reason.
I think I saw a suggestion to carry a fixed blade knife, but IIRC, that will run you afoul of Seattle's laws. I like the Doug Ritter (full size) RSK, and have a backup knife in my pack.
The sawzall blades stink when not attached to a sawzall. Hacksaw is probably better when human powered. I actually stopped carrying my hacksaw blade and now just rely on having a diamond file on my multitool. I think the cutters and full size pry bar are probably the right tools for most earthquake jobs. If you have the space in the office kit, just throw in a full size hacksaw.
Full size crowbar, cutters and hack saw seem like they should cover you well. Once you are on the road, your need for these tools is probably greatly reduced unless you plan to try to dig people out all the way home. If that is the case, you probably want to take the full size tools with you.
All in all, I think you have done great. I think the main thing is to keep in mind what your objectives are and then think through what you need to achieve the objective and what you don't need. Be ruthless about pruning what doesn't support your objectives -- it will give you more space for things that do.
But... give yourself the OK to make some decisions that you know are not logical. Sometimes it is OK to do what we want instead of what is logically the best answer.
For example, I carry a knife on my person, a multitool on my person, and have a backup knife in my pack. It is probably not logical given my objectives to carry the backup knife. Likewise, I probably have more light devices (flashlights, marker lights, etc.) than is strictly logical. I face it, and I'm OK with it.
From time to time unpack the kit, look it over and see what you might have taken out and forgotten to put back in, what you might have added that you don't really need, and what might have expired and what you might have changed your mind about. I just did this today after looking at your post and found all of those were true!
Good luck!
-john