Look to the ultralight crowd and see what you can learn from them...

I like the UL philosophy that you attack on two fronts: The big heavy ones AND the total accumulated mass of all the little things. One added benefit is that the total number of items is reduced, which reduces complexity and makes it A LOT easier to find stuff.

Their primary targets would be the biggest, bulkiest and heaviest single items: Your pack, your sleeping bag and your shelter (tent/tarp/whatever). Unfortunately, they are also the most expensive to replace with good UL alternatives.

The backpack can be much lighter if the load inside it is reduced in weight and volume. It's a negative feedback at play: The bulkier / heavier gear, the heavier your pack must be to provide comfort with the heavy load.

Another thing to learn from UL people is the thoroughness they apply when composing the gear list, always looking for multi-purpose items and discarding single-use items. There is no law that dictates that you cannot have redundancy for critical gear (knife, fire etc.) through multi-use items. Example: Your multitool is also the handle for lifting pots off the fire (the dedicated handle is then left at home), a backup knife and a backup saw.

Learning from UL people and applying to your situation does not make you UL ... I'll never be in the UL crowd, but I do try to cut down on superfluous redundancy. Personally, I think the cutting the toothbrush and removing the labels are more UL rites-of-passage than anything else.