Practical:
Will, updated and reviewed with PR;
Plan, or at least make your wishes known, for your funeral;
Advance Medical Directive, a.k.a. "Living Will;"
Designation of Health Care Surrogate, with full discussion;
Keep spouse/family involved and informed as to finances, etc.;
Keep personal records, important papers, instruction manuals, maintenance records, etc. organized and accessible;
Keep spouse/family informed of all those little things you routinely handle yourself, and make sure they know how to do them themselves, like changing furnace filters or rotating tires.

Personal:
Don't leave unsaid those things you want to or should say;
Apologize for and try to amend your errors as soon as possible;
Forgive others, and don't carry grudges;
Treat your spouse, family and friends as if today will be their last memory of you;
Focus more on life's experiences and less on life's material concerns;
Regret for things left undone and remorse for things done are burdens you don't have to inflict on yourself. So get off your duff and do the things you've always wanted or meant to do, but take care and think ahead, too;
"Yesterday is history, tomorrow is a mystery, but today is a gift. That's why we call it the 'present.'"